Study on the polymorphism of interleukin-1 gene and the susceptibility to essential hypertension.
- Author:
Yan LI
1
;
Pu XU
;
Ping-an ZHANG
;
Xiao-yan LI
;
Cong-xin HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Female; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; genetics; Interleukin 1 Receptor Antagonist Protein; genetics; Interleukin-1alpha; genetics; Interleukin-1beta; genetics; Male; Middle Aged; Minisatellite Repeats; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2004;21(5):491-493
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo make investigations on the polymorphism of interleukin-1 (IL-1)gene in Chinese Han population, on its association with essential hypertension, and on the relationship between the genotype of IL-1 and susceptibility to essential hypertension.
METHODSThe polymorphisms of IL-1 gene in Han population of Hubei province, including polymorphisms of IL-1alpha (-889C/T), IL-1beta (-511C/T),IL-1beta (+3953C/T), IL-1Ra(+8006T/C) and IL-1Ra (variable number of tandem repeat, VNTR), were analyzed by polymerase chain reaction (PCR) and a combination of PCR-restriction fragment length polymorphism methods in 152 patients with essential hypertension and 168 healthy controls.
RESULTSThe polymorphism distributions of IL-1alpha (-889C/T), IL-1beta (+3953C/T), IL-1Ra (+8006T/C) and IL-1Ra (VNTR) showed no differences between the essential hypertension group and control group, but the IL-1beta (-511C/T) exhibited a significant difference between the two groups. CT genotype carriers were at increased risk for essential hypertension (OR=2.54, 95%CI: 1.41-4.58), compared with healthy controls.
CONCLUSIONThe polymorphism of promotor region -511C/T in IL-1beta gene is probably associated with the susceptibility to essential hypertension.
