Associations between CYP11B2 gene -344T/C polymorphism and essential hypertension in the Han nationality in Shandong province.
- Author:
Xiao-jian SUN
1
;
Xiao-fei HOU
;
Shao-rong LIU
;
Wen-bo LIU
;
Zhi-gang TAO
;
Jian-yuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; China; Cytochrome P-450 CYP11B2; genetics; Female; Humans; Hypertension; ethnology; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2004;21(5):502-504
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate whether the -344T/C polymorphism of CYP11B2 gene is associated with essential hypertension in the Hans in Shandong province.
METHODSPlasma renin activity (PRA) and plasma aldosterone concentration (PAC) were measured with radioimmunoassays; the hypertensives were classified as low-renin and normal- or high-renin group by PAC/PRA ratio. -344T/C polymorphism was determined by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) in controls and hypertensives.
RESULTSNo significant differences were found in genotype distribution or allele frequency between groups of control and primary hypertension or between groups of control and normal- or high-renin hypertension. The C allele frequency in low-renin hypertension group was significantly higher than that in normotensives and normal- or high-renin hypertension group (P < 0.05).
CONCLUSIONThese results suggest that -344T/C polymorphism of CYP11B2 gene may be associated with low-renin essential hypertension in the Han nationality in Shandong province.
