Total cholesterol mediates the effect of ABO blood group on coronary heart disease
10.3760/cma.j.issn.0253-3758.2015.05.006
- VernacularTitle:ABO血型与冠心病及血脂的相关性
- Author:
Ping GONG
1
;
Sha LI
;
Liangyan HU
;
SongHui LUO
;
JianJun LI
;
Hong JIANG
Author Information
1. 武汉市第五医院
- Keywords:
Coronary disease;
ABO blood-group system;
Cholesterol
- From:
Chinese Journal of Cardiology
2015;43(5):404-407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find a potential link among ABO blood group,lipid profiles and coronary artery disease (CAD) and to estimate the effect size of connection using mediation analysis model.Methods A total of 898 consecutive patients undergoing coronary angiography were enrolled,and divided into CAD group and non-CAD group according to angiographic findings.According to ABO blood group,patients were divided into O blood group and non-O blood group,as well as A blood group and non-A blood group.Baseline characteristics among various groups were compared and the association of ABO blood group,CAD and lipid profile was explored.Results Subjects of blood type A had higher concentration of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) compared with that of non-A type (TC:(4.43 ± 1.12) mmol/L vs.(4.18 ± 1.09) mmol/L,LDL-C:(2.79 ±0.99) mmo/L vs.(2.59-± 1.01) mmol/L,all P ＜ 0.01).TC and LDL-C were significantly higher while high density lipoprotein cholesterol (HDL-C) and ApoA Ⅰ levels were significantly lower in CAD group than in non-CAD group (TC:(4.36 ± 1.05) mmol/L vs.(4.13 ± 1.16)mmol/L,LDL-C:(2.61 ±0.87) mmol/L vs.(2.47 ±0.94) mmol/L;ApoA Ⅰ:(1.38 ± 0.29) mmol/L vs.(1.45 ± 0.33) mmol/L;all P ＜ 0.01).After adjustment for traditional cardiovascular risk factors,blood group A and TC remained significantly associated with the risk of CAD (OR =1.88,95％ CI 1.280-2.774,P ＜0.01;OR =1.03,95％ CI 1.018-1.033,P ＜0.01,respectively).Specially,mediation analysis indicated that 10.5％ of the effect of A blood group on CAD was mediated by TC levels (P ＜0.01).Conclusion Our data indicate that there is an association between ABO blood group,TC levels and risk of CAD.Around 10.5％ of the effect of A blood group on CAD is mediated by TC levels.
