Study of methylation of promoter of EYA1 gene in microtia.
- Author:
Lin LIN
1
;
Bo PAN
;
Hai-yue JIANG
;
Hong-xing ZHUANG
;
Yan-yong ZHAO
;
Qing-hua YANG
;
Le-ren HE
;
Juan HAN
;
Shu-jie WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Child, Preschool; CpG Islands; DNA Methylation; Ear; abnormalities; Female; Humans; Intracellular Signaling Peptides and Proteins; genetics; Male; Middle Aged; Nuclear Proteins; genetics; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; genetics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Young Adult
- From: Chinese Journal of Plastic Surgery 2009;25(6):436-439
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the methylation of CpG islands in promoter of eye absent gene 1 (EYA1) in microtia.
METHODSThe methylation of CpG islands in EYA1 gene in 64 microtias and 36 healthy controls were measured using the technique of matrix-assisted laser desorption/ionization-time of flight.
RESULTSThe methylation of CpG_Unit3 and CpG_Unit5 of EYA1 gene in microtia were 0.09258 +/- 0.033846 and 0.0922 +/- 0.02379, respectively, which were significantly lower than those in control.
CONCLUSIONSHypomethylation in microtia may be related to the pathogenesis of the disease.
