Distraction osteogenesis for correction of cleft palate in rhesus-histological and fluorescent labeling study.
- Author:
Yi LIU
1
;
Gang CHEN
;
Yan-shan LIU
;
Dai SHEN
;
Tong ZHU
;
Zhi-qi WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biomarkers; Cleft Palate; pathology; surgery; Macaca; Osteogenesis, Distraction; Palate, Hard; pathology; Palate, Soft; pathology
- From: Chinese Journal of Plastic Surgery 2010;26(1):43-47
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the mechanism of new bone formation in the distraction osteogenesis (DO) for correction of cleft palate (CP) in rhesus.
METHODSCP was created by operation in 23 rhesus. The CP was corrected with DO in 21 animals as experimental group. The distraction rate was 0.8 mm per day, two times a day. The bone fragments were fixed after cleft closure, every 3 animals were sacrificed to get specimen after 1, 2, 4, 6, 8, 12, 24 weeks of fixation. 6 days before sacrifice, tetracycline was administrated for labeling (30 mg/kg).
RESULTSThe hard and soft tissue def of fixation. At the same time, the bone volume and calcification between the distraction gap increased. The cleft in the control group could not b ect was successfully closed with DO by intramembrane osteogenesis. The new formed bone was remodeling and became maturation during the period e corrected spontaneously.
CONCLUSIONSThe DO can successfully correct both the soft and hard tissue defect in CP by intramembrane osteogenesis. The fixation is important for remodeling and maturation of the new formed bone.
