Relation of HLA-DRB1*15 with pathogenesis in 162 childhood cases of acute lymphoblastic leukemia.
- Author:
Xiao-Jing WANG
1
;
Xiao-Fei AI
;
Hai-Yan SUN
;
Fang WANG
;
Shi-Cai XU
;
Fu-Min GUI
;
Hui SHEN
;
Zhi-Qiang WANG
;
Qing-Hua LI
;
Xiao-Lan LIANG
;
Xiao-Fan ZHU
Author Information
1. Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Scinces & Peking Union Medical College, Tianjin 300020, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Case-Control Studies;
Child;
Child, Preschool;
Female;
Gene Frequency;
HLA-DR Antigens;
genetics;
HLA-DRB1 Chains;
Humans;
Infant;
Male;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
genetics
- From:
Journal of Experimental Hematology
2009;17(6):1507-1510
- CountryChina
- Language:Chinese
-
Abstract:
To unravel the relation of HLA-DRB1*15 with childhood acute lymphoblastic leukemia (ALL), 162 childhood patients with ALL were selected for this investigation. 1 000 normal umbilical cord blood samples were used as control.HLA-DRB1*15 and HLA-DRB5* were typed by polymerase chain reaction (PCR) analysis. The relation of HLA-DRB1*15 with childhood ALL was studied by calculating the chi-square test and relative risk. The results showed that the antigen frequencies and allele frequencies of HLA-DRB1*15 in childhood patients with ALL were 40.12% and 22.62% respectively, while the antigen frequencies and allele frequencies of HLA-DRB1*15 in control were 30.80% and 16.81% respectively, there were significant difference between them (chi(2) = 5.560, p = 0.018, RR = 1.506). In conclusion, the antigen frequencies and allele frequencies of HLA-DRB1*15 in childhood patients with ALL were higher than those in control, so the HLA-DRB1*15 gene is one of the genetic risk factors for childhood ALL. These preliminary data may be useful for further study on the pathogenesis of childhood ALL.
