Evaluation for reliability of 13C-Urea breath test and other biopsy-based methods in H. pylori diagnosis.
- Author:
Vinh Thuy Nguyen
- Publication Type:Journal Article
- Keywords:
bacterium
- MeSH:
Helicobacter pylori;
diagnosis
- From:Journal of Practical Medicine
2002;435(11):41-44
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Multiple tests are available to diagnose Helicobacter pylori. The aim of this study was to evaluate and compare the sensitivity, specificity and negative and positive predictive values of 13C-Urea breath test (13C-UBT) and other biopsy-based methods in H. pylori diagnosis. A total of 702 patients (mean age, 51.2+/-16.0 years; 327 males and 375 females) were tested for H. pylori infection using 13C-UBT, CLO tests (Delta West, Australia), histology (H&E and modified Giemsa stains), and culture. All patients were untreated for H. pylori infection. Infection status was established by Gold Standard (or culture positive of 2 out of 3 other tests positive). Results suggested that 13C-UBT was the most accurate method for H. pylori diagnosis, although CLO test and histology also produced excellent sensitivity and specificity. Culture method had the best specificity; however, it produced the lowest sensitivity. Combination of histology and CO test gave higher sensitivity and specificity than each method used individually. Conclusion: The noninvasive 13C-BUT is excellent accurate method for determining H. pylori infection when endoscopy is not required. Histology, CLO test and culture are also good methods for H. pylori diagnosis.
