A randomized double-blind placebo-controlled study of Pu'er tea extract on the regulation of metabolic syndrome.
- Author:
Song-Ling CHU
1
;
Hong FU
;
Jin-Xia YANG
;
Geng-Xin LIU
;
Pan DOU
;
Liang ZHANG
;
Peng-Fei TU
;
Xue-Mei WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Blood Glucose; metabolism; Body Mass Index; Double-Blind Method; Drugs, Chinese Herbal; adverse effects; therapeutic use; Female; Humans; Inflammation; blood; complications; Lipids; blood; Male; Malondialdehyde; blood; Metabolic Syndrome; blood; complications; drug therapy; Middle Aged; Oxidation-Reduction; Placebos; Plant Extracts; therapeutic use; Superoxide Dismutase; blood; Waist-Hip Ratio
- From: Chinese journal of integrative medicine 2011;17(7):492-498
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore the regulative efficacy of Pu'er tea () extract on metabolic syndrome.
METHODSNinety patients with metabolic syndrome were randomly divided into two groups, the intervention group administered with Pu'er tea extract, and the placebo group with placebo capsules. After 3 months' treatment, body mass index, waist hip ratio, blood lipids, blood sugar, immune and inflammatory index, and oxidation index of the patients with metabolic syndrome were tested and analyzed.
RESULTSIn the intervention group, the body mass index, waist-hip ratio, fasting and 2 h postprandial blood glucose, serum total cholesterol, triglycerides, low density lipoprotein and apolipoprotein B-100 all decreased in the patients with metabolic syndrome, and also the high-density lipoprotein level increased and apolipoprotein A-1 showed the tendency to increase. Serum C-reactive protein, tumor necrosis factor-α, and interleukin-6 were decreased in the intervention group. Interleukin-10 level was increased, MDA was decreased and superoxide dismutase was increased. Compared with before treatment and the placebo group, there were significant differences (P<0.05, P<0.01).
CONCLUSIONSPu'er tea demonstrated excellent potential in improving central obesity, adjusting blood lipid, lowering blood sugar, regulating immunity and resisting oxidation. It can adjust the metabolic syndrome of different clinical phenotypes to different degrees, and is ideally fit for early prevention of metabolic syndrome.
