Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances.
- Author:
Qiong-lan TANG
1
;
Wei-ping LIU
;
Wen-yan ZHANG
;
Fan YANG
;
Miao-xia HE
;
Qing-jie XIA
;
Gan-di LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Cysteine-Rich Protein 61; Female; Humans; Immediate-Early Proteins; biosynthesis; genetics; Intercellular Signaling Peptides and Proteins; biosynthesis; genetics; Killer Cells, Natural; Lymphoma, T-Cell; metabolism; pathology; Male; Middle Aged; Nose Neoplasms; metabolism; pathology; Polymerase Chain Reaction; RNA, Messenger; biosynthesis; Vascular Endothelial Growth Factor A; biosynthesis; genetics
- From: Chinese Journal of Hematology 2006;27(10):661-665
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and its significance.
METHODSCYR61 mRNA and VEGF mRNA were detected by real-time fluorescence quantitative PCR method in 20 cases of extranodal nasal-type NK/T cell lymphoma. Expressions of CYR61 and VEGF were studied by immunohistochemistry in 40 cases of the tumor.
RESULTS(1) Over-expression of CYR61 mRNA and VEGF mRNA was found in 19/20(95.0% ) and 15/20(75.0% ) cases, respectively. (2)Tumor cells expressing CYR61 protein and VEGF protein were detected in 38(95.0% ) and 25 (62. 5% ) of the 40 cases respectively, being no significant difference from the control. Co-expression of CYR61 and VEGF at both the mRNA and protein levels was 95.0% and 65.0% , respectively. Over-expression of CYR61 and VEGF at both mRNA and protein levels was found in 8 of the 40 cases. (3) The prognosis of the patients over-expressing CYR61 and VEGF was worse.
CONCLUSIONIn extranodal nasal-type NK/T cell lymphoma, the expression level of CYR61 and VEGF was changed and it may be of prognostic implication of
