The value of serum galactomannan detection for diagnosis of invasive aspergillosis in hematopoietic stem cell transplant recipients.
- Author:
Yu JI
1
;
Dai-Hong LIU
;
Lan-Ping XU
;
Kai-Yan LIU
;
Xiao-Jun HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aspergillosis; blood; diagnosis; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; methods; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Mannans; blood; Postoperative Complications; blood; diagnosis; Sensitivity and Specificity
- From: Chinese Journal of Hematology 2007;28(2):83-86
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the value of serum galactomannan (GM) detection for diagnosis of invasive aspergillosis (IA) in hematopoietic stem cell transplant recipients.
METHODSThe serum GM concentration in 167 sera from 46 patients was detected by Platelia Aspergillus double-sandwich enzyme linked immunosorbent assay (PADSELISA). According to the diagnostic criteria of invasive fungal infections in China, the diagnostic changes were evaluated, the sensitivity, specificity and predictive values were calculated.
RESULTSThe sensitivity and specificity of the PADSELISA were 81.8% and 93.3% and the positive and negative predictive values were 90.0% and 87.5% respectively. There were 15 positive cases, and 31 negative cases, and the probable IA cases were increased from 11 to 19 after the GM detection. Moreover, the serous level of galactomannan was correlated with the prognosis of the IA.
CONCLUSIONSThe PADSELISA for GM detection is a reliable method for early diagnosis and treatment of IA in hematopoietic stem cell transplant recipients.
