Splenic T-cell and NK-cell lymphomas: a clinicopathologic and immunophenotypic analysis of 9 cases.
- Author:
Zheng LI
1
;
Wei-Ping LIU
;
Yuan TANG
;
Li-Li JIANG
;
Wen-Yan ZHANG
;
Cheng-Feng BI
;
Gan-Di LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Female; Follow-Up Studies; Gene Rearrangement; Humans; Immunophenotyping; Lymphoma, Extranodal NK-T-Cell; genetics; immunology; pathology; Lymphoma, T-Cell, Peripheral; genetics; immunology; pathology; Male; Middle Aged; Splenic Neoplasms; genetics; immunology; pathology
- From: Chinese Journal of Hematology 2007;28(4):217-222
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the clinicopathologic features and diagnosis of splenic T-cell and NK-cell neoplasms.
METHODSNine cases of splenic T-cell and NK-cell neoplasms were collected and studied by morphology, immunophenotyping, EBER in situ hybridization and TCR-gamma gene rearrangement. Antibodies used were as follows: CD45RO, CD3epsilon, CD3, CD4, CD8, CD56, TIA-1, GranzymeB, CD30, Ki-67 and CD20.
RESULTSAmong the 9 cases, hepatosplenic T-cell lymphoma (HSTCL) and extranodal nasal type NK/T-cell lymphoma (NK/TCL) were both of 4 cases, and the remaining one was peripheral T-cell lymphoma, unspecified (PTL, unspecified). Follow up data were available for 7 cases. Five patients including 2 with HSTCL, 2 with extranodal nasal type NK/TCL and one with PTL, unspecified died, with survival times ranged from 1 to 10 months. The other two patients are still alive, one with NK/TCL (two months+) and one with HSTCL (14+ months).
CONCLUSIONSplenic T-cell and NK-cell neoplasms are a group of uncommon lymphomas with heterogeneous clinicopathologic features and poor prognosis. A definite diagnosis must depend on clinical manifestations, histopathology, immunophenotype and TCR gene rearrangement analysis.
