Preliminary study of the effect of HLA-Cw on haploidentical hematopoietic stem cell transplantation.
- Author:
Ming-zhen YANG
1
;
De-pei WU
;
Hui-ying QIU
;
Xiao-wen TANG
;
Miao MIAO
;
Zheng-ming JIN
;
Xiao-jin WU
;
Ai-ning SUN
;
Wei-rong CHANG
;
Jun HE
;
Wen-ying DI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Female; Follow-Up Studies; Graft vs Host Disease; immunology; HLA-C Antigens; immunology; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Survival Rate; Transplantation, Homologous; immunology
- From: Chinese Journal of Hematology 2007;28(6):407-410
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of HLA-Cw on haploidentical hematopoietic stem cell transplantation (HHSCT) without T-cell depletion.
METHODSHLA-Cw were detected with PCR-SSP, the clinical data of 21 cases of haploidentical hematopoietic stem cell transplantation, including 8 standard risk and 13 high risk cases from July 2002 to March 2006 were summarized, and the effect of HLA-Cw in HHSCT was analyzed.
RESULTSTwenty patients achieved sustained, full-donor-type engraftment. The HLA-Cw matched and mismatched groups attained neutrophil recovery at a median of 12 days and 13 days, and platelet recovery to more than 20 x 10(9)/L at a median of 20 days and 23 days respectively (P > 0.05). The cumulative incidences of grades II-IV acute GVHD were 76.9% in HLA-Cw matched group and 14.3% in the mismatched group(P < 0.05). The incidences of chronic GVHD were 85.7% in HLA-Cw matched group and 57.1% in the mismatched group(P > 0.05). The 28 months disease-free survival probabilities were 49.0% in HLA-Cw matched group, and 85.7% in the mismatched group (P > 0.05). The Karnofsky score of survival patients was over 90%.
CONCLUSIONHLA-Cw mismatched in donor and recipient of HHSCT is beneficial for reducing II-IV aGVHD, and being in favor of long term survival.
