Histopathologic features of squamous cell carcinoma.
- Author:
Kyung Shik MIN
;
Jong Min KIM
;
Eil Soo LEE
- Publication Type:Original Article
- Keywords:
Squamous Cell Careinoma;
Histopathology
- MeSH:
Abscess;
Basophils;
Biopsy;
Carcinoma, Squamous Cell*;
Dermis;
Epidermis;
Fibrosis;
Foreign-Body Reaction;
Hemorrhage;
Humans;
Incidence;
Necrosis;
Parakeratosis;
Skin Neoplasms;
Ulcer
- From:Korean Journal of Dermatology
1993;31(6):851-856
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Squamous cell carcinoma(SCC) is one of the most conimon forms of skin cancer that arises from the surface epidermis. Although many authors have reported on the incidence and clinical features of SCC, we could not find any reports concerning the widerange of histopathologic features of a number of cases of SCC in Korean dermatologic literature. OBJECTIVE: We examined the histopathologic features of SCC. METHOD: Twenty six biopsy specimens from 26 patients with SCC were examined microscopically including the tumors themselves and surrounding epidermis and dermis on routine histologic staining. RESULTS: Grade 1 tumor was found in 15 cases, grade 2 in 8 casese, and grade 3 in 3 cases. Eighteen cases showed keratin pearls, and 11 cases showed squamous eddies. P cantholysis of tumor cells was found in all 26 cases, but glandular structure was found only in 5 cases. The epidermis overlying the tumor showed hyperkeratosis and parakeratosis in all 26 cases, follicular plug in 13 cases, and ulceration in 18 cases. The dermis beneath the tumor showed vessel dilataticn, hemorrhage, and infiltration of inflammatory cells in all 26 cases, and basophilic degeneration in 1.3 cases, fibrosis in 20 cases, lichenoid reaction in 6 cases, and necrosis in 6 cases. Rare dermal findings were abscess, foreign body reaction calcification and Russell body. CONCLUSION: The histopathologic findings of SCC were variable not inly those of the tumors themselves, but also those of the surrounding epidermis and dermis.
