Ingredients of Shuanghuanglian injection powder permeation through placental barrier of rat in pregnancy.
- Author:
Dianrong SONG
1
;
Jie GUO
;
Yuefei WANG
;
Guixiang PAN
;
Peilin LI
;
Wei ZHANG
;
Hongyun SONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; administration & dosage; analysis; metabolism; Female; Humans; Injections; Male; Models, Animal; Permeability; Placenta; drug effects; metabolism; Pregnancy; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2010;35(12):1626-1629
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEUse HPLC to study the permeation of ingredients of Shuanghuanglian injection powder (SHL) through placental barriers of rats at different stages of pregnancy.
METHODThe pregnant rats were administered SHL for 5 d through caudalis vena at different stages of pregnancy. Plasma and embryonic tissues were obtained 12 h after the final administration of SHL. The componds in biological specimen were identified by HPLC.
RESULTBaicalin, luteolin and wogonoside were the main compounds in plasma. Wogonoside retained in first trimester embryonic tissues, and baicalin retained in the embryonic tissues of different pregnant stages.
CONCLUSIONBaicalin is the main compound of SHL through placental barriers of rats. Embryotoxicity of baicalin should be considered as the key point to evaluate the safety of SHL.
