In vitro senstivity of sporothrix schenckii against antifungal agents.
- Author:
Moo Kyu SUH
;
Yeol Oh SUNG
;
Hwa Sung KIM
- Publication Type:In Vitro ; Original Article
- Keywords:
Minimal Inhibitory Concentration;
Sporothrix schenckii
- MeSH:
Amphotericin B;
Antifungal Agents*;
Dimethyl Sulfoxide;
Ethanol;
Hyphae;
Itraconazole;
Ketoconazole;
Potassium Iodide;
Spores;
Sporothrix*;
Sporotrichosis;
Water
- From:Korean Journal of Dermatology
1993;31(6):884-889
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Despite concern about treatment of sporotrichosis, little is known about the sensitivity of S. schenckii against antifungal agents. OBJECTIVE: The purpose of the study was to investigate minimal irihibitory concentration(MIC) of antifungal agents against S.chenckii. METHOD: The tested strains were seven in number. The tested antifngal agents were ketoconazole, itraconazole, amphotericin B, and potassium iodide. A various concentration of drugs were mixed into fluid media containing 50% ethanol, dimethyl sulfoxide, and distilled water. The inoculum consisted of 3mm block containing hyphae and spores. RESULTS: MIC ranges of ket.oconazole, itraconazole, amphotericin B, and potassium iodide were 0.39- 25pg/ml, 0.78-25pg/ml, 0.78-25pg/ml, and 75-550pg/ml, respectively. CONCLUSION: We find that ketoconazole is the most active drug against S. schenckii.
