Study on antioxidant effect of Herba Lycopi and screening of active fractions.
- Author:
Bo NIE
1
;
Feng HUANG
;
Yong LIU
;
Guanhua DU
;
Xinmiao LIANG
;
Peigen XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antioxidants; analysis; pharmacology; Lipid Peroxidation; drug effects; Lycopus; chemistry; Male; Microsomes, Liver; drug effects; metabolism; Plant Extracts; analysis; pharmacology; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2010;35(13):1754-1757
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo Study the antioxidant activity of Herba Lycopi, and screen the main active fractions.
METHODThe different polar fractions were isolated from the ethanol extract of Herba Lycopi. The scavenging activity to DPPH and superoxide anions, reducing effect on Fe3+, and inhibiting activity of lipid peroxidation of the fractions were studied in vitro by high-throughput screening technique.
RESULTThe ethanol extract, ethyl acetate fraction (LLE-A. E, MCCM2921) and n-buthanol fraction (LLE-A. B, MCCM2922) of Herba Lycopi showed the scavenging activity to DPPH and superoxide anions, reducing effect on Fe3+, and inhibiting activity of lipid peroxidation.
CONCLUSIONThe ethanol extract and different polar fractions showed antioxidant capacity in vitro. That may be explain that the effect of activating blood and dissolving stasis and anti-fibrosis of Herba Lycopi in traditional application. The results may be helpful for further development of Herba Lycopi as a low-toxic antioxidant drug.
