Hasubanan type alkaloids in Stephania hernandifolia.
- Author:
Lijia TANG
1
;
Yuanhu ZHANG
;
Xiaoyan HAO
;
Li HE
;
Shaohui SONG
;
Xiaojiang HAO
;
Xiaosheng YANG
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; chemistry; isolation & purification; Chemical Phenomena; Molecular Structure; Plant Extracts; chemistry; isolation & purification; Stephania; chemistry
- From: China Journal of Chinese Materia Medica 2010;35(15):1973-1977
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the hasubanan type alkaloids in Stephania hernandifolia.
METHODThe dried herbs of S. hernandifolia. were extracted with 95% ethanol. After removal of the solvent, the residue was first partitioned between acid water and petroleum ether, then the aqueous layer was basified and extracted with chloroform to obtain crude alkaloids. Column chromatograghic methods with on silica gel, Rp-18, MCI CHP 20P, Sephadex LH-20 were applied for the isolation and purification of the crude alkaloid fraction. The structures were elucidated by their physicochemical properties and spectral data.
RESULTNine hasubanan type alkaloids were obtained and identified as aknadinine(1), longanone(2), stephasunoline (3), N-methylstephuline(4), epistephamiersine(5), prostephabyssine(6), aknadilactam(7), dihydroepistephamiersine(8), hasubanonine(9).
CONCLUSIONCompounds 2-8 were isolated from this plant for the first time.