Comparative study on acute toxicity and pharmacological effect of huoxiang zhengqi microemulsion and huoxiang zhengqi tincture.
- Author:
Yanli LU
1
;
Bo PENG
;
Rong HE
;
Jie GAO
;
Hua YANG
;
Hong YI
;
Jiangrong LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antidiarrheals; administration & dosage; toxicity; Diarrhea; drug therapy; Disease Models, Animal; Dosage Forms; Drugs, Chinese Herbal; administration & dosage; toxicity; Emulsions; Humans; Male; Mice; Mice, Inbred ICR
- From: China Journal of Chinese Materia Medica 2010;35(15):2004-2007
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the acute toxicity and the pharmacological effect of Huoxiang Zhengqi microemulsion and Huoxiang Zhengqi tincture.
METHODThe acute toxicities of Huoxiang Zhengqi microemulsion and Huoxiang Zhengqi tincture were observed by the test of maximum dose in mice and the antidiarrheal effects of them were evaluated by ED50 values of the diarrhea index, the serum levels of gastrin and motilin in the mice diarrhea model induced by senna.
RESULTThe acute toxicity of Huoxiang Zhengqi tincture was much higher than that of Huoxiang Zhengqi microemulsion and the ED50 values of the two formulations were similar.
CONCLUSIONThe microemulsion of Huoxiang Zhengqi prescription was much safer than that of tincture, but the antidiarrheal effects of them in diarrhea model induced by senna were similar.
