Formulation optimization of gel matrix of Saussurea involucrate by orthogonal design.
- Author:
Xianhui HUANG
1
;
Jianguo XING
;
Xinchun WANG
;
Ping LU
;
Weijun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; Dosage Forms; Drugs, Chinese Herbal; chemistry; Saussurea; chemistry
- From: China Journal of Chinese Materia Medica 2010;35(14):1803-1805
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the formulation of gel matrix of Saussurea involucrate.
METHODThe formulation of gel containing carbopol, azone, trimethylene glycol and alcohol was optimized by orthogonal design with evaluation indexes such as consistency in room temperature, consistency of average temperature of skin, yield value and rheopexy in room temperature.
RESULTThe optimal proportion of matrix components was made from carbopol-azone-trimethylene glycol-absolute alcohol (2. 0: 2. 0:15.0 : 30.0).
CONCLUSIONThe optimal formulation of S. involucrate gel based the optimal formulation is well-distributed and transparent, it has proper consistency and well rheopexy.
