Study on extracting process of ethanol extract with hypouricemic effect from rhizoma alismatis.
- Author:
Jianping WANG
1
;
Xuchun FU
;
Haibo BAI
Author Information
- Publication Type:Journal Article
- MeSH: Alismataceae; chemistry; Animals; Chemical Fractionation; methods; Disease Models, Animal; Ethanol; chemistry; Humans; Hyperuricemia; blood; drug therapy; Mice; Plant Extracts; administration & dosage; Rhizome; chemistry; Uric Acid; blood; Uricosuric Agents; administration & dosage
- From: China Journal of Chinese Materia Medica 2010;35(14):1809-1811
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the extracting process of ethanol extract with hypouricemic effect from Rhizoma Alismatis.
METHODOrthogonal design was utilized to optimize the preparing conditions including the concentration of ethanol, amount of ethanol, extraction times and extraction duration per time while alisol B 23-acetate was selected as the evaluation index. Both the alisol B 23-acetate and the serum uric acid levels were measured by HPLC.
RESULTThe ethanol extract had hypouricemic action. Only extraction times had significant effect on the content of alisol B 23-acetate in ethanol extract.
CONCLUSIONThe optimal extraction process is to extract two times using sevenfold 70% ethanol and 1 h per time.
