The research progress of one member of the EF-hand superfamily--troponin C.
- Author:
Jian-Qing CHEN
1
;
Yao-Zhou ZHANG
Author Information
1. Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.
- Publication Type:Journal Article
- MeSH:
Amino Acid Sequence;
Animals;
Binding Sites;
genetics;
Bombyx;
genetics;
metabolism;
Calcium;
metabolism;
EF Hand Motifs;
Molecular Sequence Data;
Phylogeny;
Protein Binding;
Troponin C;
classification;
genetics;
metabolism
- From:
Chinese Journal of Biotechnology
2007;23(3):375-380
- CountryChina
- Language:Chinese
-
Abstract:
The EF-hand superfamily is a large group of proteins which contain EF-hand motif formed by helix-loop-helix. These proteins always have the ability of binding metal ions or forming dimmers. Troponin C, known as having ability of binding Ca2+, is one member of the EF-hand superfamily. Troponin C interacts with troponin I and troponin T, forming a troponin complex which takes part in regulating muscle contraction. It is interesting that troponin C was also found in non-muscular tissue, and its function was proved to be different from that of troponin C found in muscular tissue. To date, a lot of researches about troponin C have been carried out widely. However, most of them focused on vertebrate, seldom were done on invertebrate. Our group carried out a research on troponin C from silkworm, a model organism of insects, aiming to clarify the structure and function of silkworm troponin C. Here, we mainly discuss the characters of the EF-hand superfamily and the classification, structure and function of troponin C . We also introduced our work about silkworm troponin C briefly, hoping of making a little contribution to the research of invertebrate troponin C.
