Pharmacokinetic comparison of baicalin absorption medicine Qinbai Qingfei concentrated pellets drug compatibility.
- Author:
Hai-Long LI
;
Wen-Cheng FENG
;
Lin YAO
;
Yan SUN
;
Ya-Juan SONG
;
Hao HU
;
Wei-Ming WANG
- Publication Type:Journal Article
- MeSH:
Animals;
Area Under Curve;
Drugs, Chinese Herbal;
analysis;
pharmacokinetics;
Flavonoids;
blood;
pharmacokinetics;
Intestinal Absorption;
Male;
Rats;
Rats, Wistar
- From:
China Journal of Chinese Materia Medica
2014;39(10):1933-1936
- CountryChina
- Language:Chinese
-
Abstract:
The Qinbai Qingfei concentrated pellets by traditional Chinese medicine theoryand party and group, the rats were given the drugs group, comparison of pharmacokinetics parameters changes of baicalin , discusses the rationality of Qinbai prescription. The rats were gavaged monarch drug group (Huang Qincu extract, mainly forbaicalin), and official medicine group, adjuvant group, medicine group and Qinbai group (Quan Fangzu) the content of baicalin equal as the monarch drug group, in the 28 h collection in rat plasma at different time point, application of HPLC determination of baicalin glycosides in rat plasmaconcentration time curve, with 3P97 practical pharmacokinetics program to process the data Based on the data analysis, baicalin in rat plasma of Qinbai group Cmax is 4 times as big as monarch druggroup, AUC is 6 times as big as monarch drug group; the content of baicalin in plasma of rats the highest is Qinbai group, the minister drug group, adjuvant group, medicine group of baicalin in rat plasma content of less than the Qinbai group, but was significantly higher than that of monarch drug group; the medicine group is slightly higher than that adjuvant the content of baicalin in plasma of rats. The pharmacokinetic results show that the measured plasma concentration in rats that Qinbai can significantly increase Cmax and AUC of baicalin, other components of qinbai can promoted the baicalin absorption in vivo. It showed that the reasonable of Qinbai compound compatibility. The minister drug can promote the absorption of baicalin in vivo.
