Impact of drug molecules on HP-β-CD compound inclusion.
- Author:
Dan-Dan TANG
;
Na LI
;
Li-Wen WANG
;
Ji-Fen ZHANG
;
Xiao-Yu XU
- Publication Type:Journal Article
- MeSH:
2-Hydroxypropyl-beta-cyclodextrin;
Bornanes;
chemistry;
therapeutic use;
Brain Ischemia;
drug therapy;
Drug Compounding;
methods;
Freeze Drying;
Iridoid Glucosides;
chemistry;
therapeutic use;
Isoflavones;
chemistry;
therapeutic use;
Solubility;
beta-Cyclodextrins;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(15):2893-2899
- CountryChina
- Language:Chinese
-
Abstract:
To study the interaction of drugs of different properties, namely puerarin, borneol and catalpol in the process of in- clusion, in order to explore the inclusion regularity of multi-component and multi-property traditional Chinese medicine compound in- clusions. With HP-β-CD as the inclusion material, the freeze-drying method was used to prepare the inclusion. The inclusion between puerarin, borneol and catalpol was tested by measuring the inclusion concentration, DSC and X-ray diffraction. According to the find- ings, when insoluble drugs puerarin and borneol were included simultaneously, and puerarin was overdosed, puerarin included was almost equal to puerarin included, and borneol was not included. When puerarin was under-dosed, and HP-β-CD was overdosed, borne- ol was included, and the simultaneous inclusion was lower than the separate inclusion of borneol. When water-soluble drug catalpol was jointly included with puerarin or borneol, the simultaneous inclusion was almost the same with their separate inclusion, without charac- teristic peak of catalpol in DSC and X-ray diffraction patterns. There is a competition in the simultaneous inclusion between water-solu- ble drugs puerarin and borneol and a stronger competition in puerarin. The water-soluble drug catalpol could be included with HP-β-CD with no impact on the inclusion of puerarin or borneol.
