Advance in studies on antitumor and immunomodulatory effects of wogonin.
- Author:
Wei-Ming XIAO
;
Ping BU
;
Wei-Juan GONG
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
therapeutic use;
Apoptosis;
drug effects;
Drugs, Chinese Herbal;
therapeutic use;
Flavanones;
therapeutic use;
Humans;
Immunologic Factors;
therapeutic use;
Neoplasms;
drug therapy;
immunology;
physiopathology;
Tumor Necrosis Factor-alpha;
genetics;
immunology
- From:
China Journal of Chinese Materia Medica
2014;39(16):3004-3009
- CountryChina
- Language:Chinese
-
Abstract:
Wogonin is a kind of natural flavonoid compound. According to findings in the latest studies, wogonin shows a wide range of antitumor effects, with the characteristics of multi-pathway, multi-link and multi-target, such as promoting tumor cell apoptosis through ROS or Ca(2+)-mediated signal paths, enhancing tumor cytotoxicity by TNF-α and TRAIL, blocking tumor cell cycle, inhibiting tumor angiogenesis and resisting cancer synergistically with chemotherapeutic drugs. Moreover, Wogonin could enhance body immune function by enhancing immune cell infiltration, regulating the immune cell phenotype and promoting relevant cytokine secretion. In this paper, the authors summarized the advance in studies on wogonin's antitumor and immunomodulatory effects.
