Chemical constituents from safflower injection and their bioactivity.
- Author:
Jian-Feng ZHAO
;
Jing LIU
;
Ying GUO
;
Qian LIU
;
Zhong DAI
;
Shuang-Cheng MA
;
Rui-Chao LIN
- Publication Type:Journal Article
- MeSH:
Animals;
Blood Platelets;
drug effects;
physiology;
Carthamus tinctorius;
chemistry;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
Fibrinolytic Agents;
chemistry;
isolation & purification;
pharmacology;
Molecular Structure;
Platelet Aggregation;
drug effects;
Rabbits;
Spectrometry, Mass, Electrospray Ionization
- From:
China Journal of Chinese Materia Medica
2014;39(16):3102-3106
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents of Safflower injection were isolated and purified by polyamide, silica gel, Sephadex LH-20, ODS column chromatographies and preparative HPLC. As a result, sixteen compounds have been isolated. Based on the spectral data analysis, their structures were elucidated as scutellarin (1), kaempferol-3-O-β-rutinoside(2), hydroxysafflor yellow A(3), rutin (4), coumalic acid(5), adenosine(6), syringoside(7), (3E)-4-(4'-hydroxyphenyl)-3-buten-2-one(8), (8Z)-decaene-4, 6-diyne-1-Oβ-D-glucopyranoside(9), 4-hydroxybenzaldehyde (10), (2E, 8E) -tetradecadiene-4, 6-diyne-1, 12, 14-triol-1-O-β-D-glucopyranoside (11), kaem-pferol-3-O-β-sophorose (12), uridine (13), roseoside (14), cinnamic acid (15), and kaempferol (16). Compounds 1,2,7,9,11 and 12 were isolated from the Safflower injection for the first time. The anti-platelet aggregation activities of the isolated compounds were assayed. The results indicated all tested compounds exhibited potent activity except for 5, while 2, 3, 9 and 12 showed strong activity against platelet aggregation.
