Efficacy and Safety of Tacrolimus versus Cyclosporine A for Idiopathic Membranous Nephropathy:A Network Meta-analysis.
- Author:
Ping XU
1
;
Yu-di HE
1
;
Ze-Ming YU
1
;
Kai LUO
2
;
Huai-Ya XIE
3
;
Pei-Mei ZOU
3
;
Xiao GU
1
;
Shi-Rui WANG
1
;
Jian-Fang CAI
3
;
Qun XU
2
;
Hang LI
3
;
Xue-Wang LI
3
Author Information
- Publication Type:Journal Article
- From: Acta Academiae Medicinae Sinicae 2018;40(1):41-51
- CountryChina
- Language:English
- Abstract: Objective To compare the efficacy and safety of tacrolimus with those of cyclosporine in treating idiopathic membranous nephropathy (IMN) via network meta-analysis. Methods Databases including PubMed,Embase,CENTRAL (Cochrane),Wanfang Database,CNKI,and VIP citation database were searched for relevant studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Package Meta 4.5.0 and Gemtc 0.8.1 in R 3.3.1 were used to analyze the included studies. Results In this network meta-analysis,the complete remission rate (RR=0.98,95% CI:0.70-1.40)and the total remission rate (RR=1.00,95% CI:0.90-1.20)of idiopathic membranous nephropathy did not differ significantly between IMN patients treated with cyclosporine A or tacrolimusand,nor did the incidences of hepatic dysfunction(RR=1.40,95% CI:0.52-4.00),infection(RR=0.75,95% CI:0.18-3.10),or gastrointestinal syndrome(RR=2.1,95% CI:0.36-28.00). Conclusion Cyclosporine A seems to have similar effectiveness and safety to tacrolimus in treating IMN.
