Study on the association between RANTES-403G/A as well as-28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou,China
10.3760/cma.j.issn.0254-6450.2012.12.019
- VernacularTitle:贵州省侗族、汉族人群乙型肝炎病毒感染结局与趋化因子RANTES基因-403G/A及-28C/G位点多态性研究
- Author:
Chan ZHANG
1
;
Ke-Ren SHAN
;
Yan HE
;
Chan-Juan WANG
;
Ting ZHANG
;
Yi LI
;
Jie DENG
;
Lin-Jie LI
;
Kai YANG OU
;
Zhi-Zhong GUAN
Author Information
1. 471002,洛阳市中心医院生殖助孕中心
- Keywords:
Hepatitis B virus;
Regulated upon activation normal T cell expressed and secreted;
Gene polymorphism
- From:
Chinese Journal of Epidemiology
2012;33(12):1279-1282
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between both regulated upon activation normal T cell expressed and secreted (RANTES)-403G/A,-28C/G gene polymorphism and the susceptibilities to hepatitis B virus (HBV) infection,among people with Dong and Han ethnicities,in Guizhou.Methods A total of 229 individuals with HBV persistence infection,161 HBV clearanced patients and another 200 controls were recruited to conduct a case-control study among residents with Dong or Han ethnicities.Allelic frequencies of both RANTES-403G/A and-28C/G were identified by TaqMan-MGB probe.Results Both RANTES-403G/A and-28C/G polymorphism in the HBV-persistent group,when compared to the HBV-clearances group,no significant difference was found (P＞0.05).Results from the univariate analysis showed that subjects carrying-403AG and-28GG genotype had higher risk on the susceptibility to HBV persistence infection.The distributions of RANTES-28C/G gene polymorphism between Dong minority and Han ethnicities regarding HBV persistence showed statistically significant difference (P＜0.05).There was no difference on the distributions of RANTES-403G/A gene polymorphism between Dong minority and Han ethnicities.Conclnsion Patients that carrying both RANTES-403AG and-28GG genotype had higher risk on the persistence to HBV,while RANTES-403A had contributed to the clearance of HBV infection.
