Effect of Cancer Symptoms and Fatigue on Chemotherapy-related Cognitive Impairment and Depression in People with Gastrointestinal Cancer.
10.4040/jkan.2016.46.3.420
- Author:
Pok Ja OH
1
;
Jung Ran LEE
Author Information
1. Department of Nursing, Sahmyook University, Seoul, Korea. jrwin@naver.com
- Publication Type:Original Article
- Keywords:
Mild cognitive impairment;
Neoplasm;
Fatigue;
Depression
- MeSH:
Anxiety;
Chronic Disease;
Cognition;
Cognition Disorders*;
Depression*;
Drug Therapy;
Fatigue*;
Gastrointestinal Neoplasms*;
Humans;
Mild Cognitive Impairment;
Negotiating
- From:Journal of Korean Academy of Nursing
2016;46(3):420-430
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to test a hypothetical model of chemotherapy-related cognitive impairment (CRCI) and depression in people with gastrointestinal cancer. METHODS: A purposive sample of 198 patients undergoing chemotherapy was recruited from November 2014 to July 2015. The instruments were Everyday Cognition (ECog), Hospital Anxiety Depression Scale (HADS), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), and M. D. Anderson Symptom Inventory-Gastrointestinal Cancer Module. Data were analyzed using descriptive statistics, correlation, and path analysis. RESULTS: CRCI was directly affected by cancer symptoms (β=.19, p=.004) and fatigue (β=.56, p<.001)(R²=47.2%). Depression was directly affected by fatigue (β=.48, p<.001) and CRCI (β=.27, p<.001). However, The impact of cancer symptoms on depression was confirmed through the mediating effect of CRCI. CONCLUSION: Results indicate that in patients with gastrointestinal cancer undergoing chemotherapy along with the direct physiologic effects (fatigue, symptoms) of cancer treatment may have altered cognitive function leading to depression.
