Molecular-epidemiological characteristics of HIV-1 isolated from newly diagnosed female subjects in Beijing, 2006 - 2010.
- Author:
Jing-rong YE
1
;
Xue-li SU
;
Shuang-qing YU
;
Ruo-lei XIN
;
Ming-qiang HAO
;
Hong-yan LU
;
Xia FENG
;
Xiong HE
;
Yi ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Acquired Immunodeficiency Syndrome; epidemiology; Adolescent; Adult; Aged; Child; Child, Preschool; China; epidemiology; Female; HIV-1; genetics; isolation & purification; Humans; Middle Aged; Molecular Epidemiology; Phylogeny; Young Adult
- From: Chinese Journal of Epidemiology 2013;34(1):49-52
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the molecular-epidemiological characteristics of HIV-1 strains prevailing among female people living with HIV in Beijing.
METHODSGag gene fragments from the 100 newly diagnosed female HIV-1 infections during 2006 to 2010 in Beijing were amplified, sequenced, and phylogenetically analyzed.
RESULTSEighty-two HIV-1 gag gene fragments were amplified and analyzed. 1 (1.22%), 1 (1.22%), 3 (3.66%), 23 (28.05%), 8 (9.76%), 2 (2.44%), 1 (1.22%), 18 (21.95%), 3 (3.66%), 1 (1.22%), 14 (17.07%), 4 (4.88%) and 3 (3.66%) individuals were infected with HIV-1 subtypes A1, A2, B, B', C, D, G, H, CRF01_AE, CRF02_AG, CRF07_BC, CRF08_BC and B'/C recombinants respectively.
CONCLUSIONThe subtypes circulating in female HIV infections in Beijing were more diverse than in male and the proportions of B' and rare subtypes were relatively high. Surveillance programs on HIV-1 genetic diversity should be strengthened.
