Prevalence of occult hepatitis B virus infection and its phylogenetic features among mother-teenager pairs
10.3760/cma.j.issn.0254-6450.2013.03.002
- VernacularTitle:母婴人群隐匿性乙型肝炎病毒感染及病毒株进化特征分析
- Author:
Xiao-Lian DONG
1
;
Qing-Qing YAO
;
Xue-Cai WANG
;
Hai-Tao XU
;
Xiao-Li WANG
;
Sheng-Yu CHEN
;
Zhi-Feng TANG
;
Ying-Jie ZHENG
Author Information
1. 浙江省德清县疾病预防控制中心
- Keywords:
Occult hepatitis B virus infection;
Overt hepatitis B virus Infection;
Phylogenetic analysis;
Genotype
- From:
Chinese Journal of Epidemiology
2013;34(3):210-213
- CountryChina
- Language:Chinese
-
Abstract:
Objective Prevalence of occult hepatitis B virus (HBV) infection (OBI) was investigated in a paired mother-teenager population and HBV S gene variation including overt and occult HBV,was determined.Methods A follow-up study based on an initial survey of 135 mother-teenager pairs was carried out through collection of questionnaires and blood samples HBsAg were detected by ELISA method,viral load by PCR amplification and HBV S gene by phylogenetic analysis.Results 102 pairs of subjects were followed-up.Blood samples from 94 mothers and 101children were collected.OBI prevalence in mothers was 10.0％ (6/60),significantly higher than 2.0％(2/101) in teenagers.Medians of viral load were 399.9 IU/ml and 247.6 IU/ml in overt and occult HBV strains,but without significant difference.1 occult HBV strain belonged to genotype B with serotype adw while the other 7 were genotype C with serotype adr.15 of the overt HBV strains belonged to genotype B with serotype adw and the other 8 were genotype C with serotype adr.Proportions of genotype-C strains were significantly higher in occult HBV strains than in overt HBV strains.Conclusion OBI was seen in teenage-mother population.
