Meta-analysis on the prognostic value of pregnancy-associated plasma protein-A in acute coronary syndrome
10.3760/cma.j.issn.0254-6450.2013.03.017
- VernacularTitle:妊娠相关蛋白A对急性冠脉综合征预后的评价
- Author:
Man LONG
1
;
Ai-Hua CHEN
;
Min-Feng DENG
;
Wen-Wen LAI
;
Yi-Hai LIANG
Author Information
1. 南方医科大学附属珠江医院心内科
- Keywords:
Pregnancy-associated plasma protein-A;
Acute coronary syndrome;
Prognosis;
Meta-analysis
- From:
Chinese Journal of Epidemiology
2013;34(3):279-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the overall prognostic effects of pregnancy-associated plasma protein-A (PAPP-A) in acute coronary syndrome (ACS)through a meta-analysis.Methods Literature was retrieved by formal searching of electronic databases (PubMed,EMBASE,OVID,Web of Knowledge,and the Cochrane Library) and by hand searching of reference lists of related articles.Random effects meta-analysis and relative risk were used to estimate the association between PAPP-A levels and adverse cardiovascular outcomes after ACS as well as preplanned subgroup analyses were conducted to identify the risk-subgroup interactions that could explain the between differences.Results A total of fourteen clinical trials were included in this Meta-analysis which involving 9413 patients.Pooled RR and their 95％ confidence intervals (CIs) for all eligible studies was 1.97 (1.49-2.60),which indicated a prognostic value of PAPP-A in patients with ACS.Differences in study design,measurement of association and duration of follow-up were responsible for the differences in results across the studies.Conclusion Our results suggested that a higher early blood PAPP-A could moderately increase the long-term risk of adverse cardiovascular outcomes and might serve as a valuable prognostic predictor in patients with ACS.
