Effect of rhodiola on serum troponin 1, cardiac integral backscatter and left ventricle ejective fraction of patients who received epirubicin-contained chemotherapy.
- Author:
Wei-sheng SHEN
1
;
Chun-heng GAO
;
Hua ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Breast Neoplasms; drug therapy; surgery; Drugs, Chinese Herbal; therapeutic use; Epirubicin; administration & dosage; adverse effects; Female; Humans; Male; Middle Aged; Myocardium; pathology; Phytotherapy; Postoperative Period; Protective Agents; therapeutic use; Rhodiola; chemistry; Stomach Neoplasms; drug therapy; surgery; Stroke Volume; drug effects; Troponin I; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2010;30(12):1250-1252
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the myocardial protective effect of Rhodiola on patients who received epidoxorubicin (EPI) treatment.
METHODSForty-two patients with myocardial damage who received 3 courses of EPI-contained chemotherapy were randomly and equally assigned to two groups, the Rhodiola treated group and the control group. After 1-month treatment, the changes in serum troponin I (cTnI) level, cardiac integral backscatter (IBS), and left ventricle ejective fraction (LVEF) in patients were observed and compared between groups.
RESULTSLevels of cTnI in the treated group and control group were (0.54 +/- 0.05) mg/L and (0.98 +/- 0.03) mg/L respectively, IBS were 55.23 +/- 5.72 scores and 61.23 +/- 5.96 scores, and LVEF (%) were 68 +/- 3 and 57 +/- 2 respectively, all showed significant differences between groups (P<0.05).
CONCLUSIONRhodiola can improve cardiac function, and suppress the increase of serum cTnI level and IBS in patients who received EPI treatment.
