Advances in the research of mechanisms of promotion of vascularization by angiogenin and its application.
- Author:
Xingang WANG
1
;
Pan WU
1
;
Chunmao HAN
2
;
Email: HANCHUNMAO1@126.COM.
Author Information
1. Department of Burns, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China.
2. Department of Burns, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China
- Publication Type:Journal Article
- MeSH:
Cell Movement;
Humans;
Neovascularization, Pathologic;
Neovascularization, Physiologic;
Ribonuclease, Pancreatic;
therapeutic use
- From:
Chinese Journal of Burns
2015;31(6):473-475
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenin, as a member of the ribonuclease superfamily, is an angiogenic protein. The angiogenic ability of angiogenin plays an important role in many physical and pathological processes. Angiogenin can induce endothelial cell migration, proliferation, tubulation, as well as inhibition of cellular apoptosis. Angiogenin can be used to modulate the angiogenetic process of tissue engineered constructions via local delivery. Furthermore, angiogenin can also be regarded as a biomarker for diagnostic evaluation of malignancy, or as a target for cancer therapy. This paper presents a comprehensive overview of the angiogenic mechanisms of angiogenin, as well as its potential application in the process of wound healing and treatment of ischemic diseases and malignancy.
