The dynamic expression of TNF-alpha mRNA of hypertrophic scars and its roles.
- Author:
Jian-lin ZHANG
1
;
Zi-hao LIN
;
Hua JIANG
;
Xiang-bin YUAN
;
Yao-zhong ZHAO
;
Jian-ming WU
;
Xiao-hai ZHU
;
Hong WU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Cicatrix, Hypertrophic; genetics; pathology; Gene Expression; Humans; RNA, Messenger; metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; genetics
- From: Chinese Journal of Plastic Surgery 2004;20(1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of tumor necrosis factor alpha: TNF-alpha in the hypertrophic scar and find a valid way to treat the hypertrophic scars with gene therapy.
METHODSTNF-alpha mRNA expression was tested with a semiquantitative reverse polymerase chain reation (RT-PCR) method in the different period of a hypertrophic scar.
RESULTSThere was a significant increase of TNF-alpha mRNA as the hypertrophic scar was getting mature (P < 0.01). However, the ratios of TNF-alpha mRNA was significantly in a lower level than the normal scar.
CONCLUSIONSThe results suggest that TNF-alpha may play an important role in normal would healing, but the hypertrophic scar may result from the shortage of the TNF-alpha. This indicates that to increase the TNF-alpha with gene therapy may be a good way to treat the hyphertrophic scar.
