Effect of lanthanum chloride on expressions of collagen protein in a wound tissue.
- Author:
Xiao-chun ZHONG
1
;
Yu-cheng DAI
;
Yong CAO
;
Guo-hui LI
;
Jie LI
;
Xie-qing WU
;
Qiang LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Collagen; biosynthesis; drug effects; Female; Lanthanum; pharmacology; Rats; Rats, Sprague-Dawley; Time Factors; Wounds and Injuries; metabolism
- From: Chinese Journal of Plastic Surgery 2004;20(1):60-62
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of lanthanum chloride on expressions of collagen protein and find a way to prevent and treat scar.
METHODSFour linear incisions were made on the dorsal skin of an adult, female Sprague-Dawley rat as an animal model. One was non-manipulated as a control; the second was injected with distilled water as a sham-control; the third was injected with 50 mmol/L of lanthanum chloride, and the fourth was injected with 50 micrograms neutralizing antibody of TGF-beta 1 as a positive control. All of the wound tissues were harvested and assayed with ABC method in 14 days and 28 days after the surgery.
RESULTSThe expressions of type I, III and IV of collagen protein in the third group significantly reduced in 14 and 28 days after the operation, compared with the control or sham-control group. Its values wen as similar as the fourth group.
CONCLUSIONLanthanum chloride could inhibit the expressions of collagen protein, and it may be used to prevent and treat scars.
