A study on the inhibiting effects of transforming growth factor-beta R II antibody on fibroblasts.
- Author:
Yu-zhu QUAN
1
;
Hong-xing ZHUANG
;
Qing-guo ZHANG
;
Yong-cheng LENG
;
Juan HANG
;
Yan-yong ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Antibodies, Monoclonal; pharmacology; Cell Division; drug effects; Cells, Cultured; Child; Fibroblasts; cytology; drug effects; ultrastructure; Flow Cytometry; Humans; Microscopy, Electron; Protein-Serine-Threonine Kinases; Receptors, Transforming Growth Factor beta; analysis; immunology
- From: Chinese Journal of Plastic Surgery 2003;19(5):377-379
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the inhibiting action of transforming growth factor-beta type R II receptor(TGF-beta R II) antibody to fibroblasts.
METHODSFour groups of cultured skin fibroblasts were treated with different dosages of TGF-beta R II antibody. Examinations were performed with HYP, MTT, microscope, and flow cytometry techniques.
RESULTSTGF-beta R II antibody resulted in significant inhibition of fibroblasts(P < 0.01).
CONCLUSIONTGF-beta R II antibody has inhibiting effects on the proliferation of skin fibroblasts and with a dose-dependent manner.
