Evaluation of a compound with dan-shen root and azone for scar treatment.
- Author:
Jiong CHEN
1
;
Chun-mao HAN
;
He-liang DONG
;
Fa-zhi QI
;
Gen-sheng CHEN
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Aged; Animals; Azepines; pharmacology; Child; Child, Preschool; Cicatrix; drug therapy; Drugs, Chinese Herbal; pharmacology; Female; Fibrinolytic Agents; pharmacology; Humans; Male; Middle Aged; Phenanthrolines; pharmacology; Phytotherapy; Rats; Skin; drug effects; pathology; Treatment Outcome
- From: Chinese Journal of Plastic Surgery 2004;20(3):219-221
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of the compound of Dan-shen root and azone for scar treatment.
METHODSThe rat skin in vitro and the human skin in vitro and vivo were separately examined their permeability of the mixture of the Dan-shen root and azone. The 301 patients with hypertrophic scar were randomly divided into two groups: one treated with elastic cloth paste (including silicone) contained in Dan-shen root with azone, and the another treated with only elastic cloth paste (including silicone).
RESULTSThe permeability of Dan-shen root with azone, passing through the rat skin in vitro and the human skin in vitro and vivo was significantly higher than both the distilled water and the normal saline (P < 0.05). In the clinical study for treatment of the hypertrophic scars, the efficient rate of the group with the Dan-shen root with azone was significantly higher than the control (91.4% vs. 71.3%) (P < 0.01).
CONCLUSIONThe Dan-shen root with azone could be easier to permeate the skin and more effective to treat the hypertrophic scar.
