The correlation between the expansion volume and the contents of b-FGF and EGF in the expanded skin.
- Author:
Xue-jun LIU
1
;
Hai-ming ZHANG
;
Guang-ci SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Epidermal Growth Factor; analysis; metabolism; Fibroblast Growth Factors; analysis; metabolism; Models, Animal; Radioimmunoassay; Skin; drug effects; metabolism; Swine; Water; administration & dosage
- From: Chinese Journal of Plastic Surgery 2004;20(3):228-230
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the correlation between the expansion with different volume and the contents of the b-FGF and EGF in the expanded skin.
METHODSThe piglets were used in the experiment,which were divided into 7 groups including the sham, the blank control,the experimental groups with inflation of 1/2 volume, 3/4 volume, full volume, 150% volume and 200% volume. When expansion was complete, b-FGF was measured using enzyme coagulate method. EGF was measured by radioimmunoassay. The data were analyzed statistically.
RESULTSThe contents of b-FGF and EGF in the expanded skin was significantly higher than normal skin (P < 0.05). The difference in contents of b-FGF and EGF between the over-expanded skin and normal skin was more significant (P < 0.01).
CONCLUSIONExpansion can lead to the increase of b-FGF and EGF contents in the expanded skin.The biological effects may be relative to epidermal hyperplasia and angiogenesis of the expanded skin.
