Expression and significance of alpha5beta1 integrin in abnormal scars.
- Author:
You YU
1
;
Guang-Zhao HE
;
Yi WU
;
Chong-Ben HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Cicatrix; metabolism; pathology; Humans; Immunohistochemistry; Integrin alpha5beta1; analysis; metabolism; Keloid; metabolism; pathology; Microscopy, Immunoelectron; Skin; chemistry; pathology; ultrastructure
- From: Chinese Journal of Plastic Surgery 2004;20(4):271-273
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of alpha5beta1 integrin in the abnormal scars and its role and significance in the formation and development of abnormal scars.
METHODSThe expression of alpha5beta1 integrin was observed in hypertrophic scar (15 samples), keloid (15 samples) and normal skin (10 samples) with SP immunohistochemical method and colloidal gold immuno-electron microscopic technique. The data were semi-quantitatively analyzed.
RESULTSThe expression levels of alpha5beta1 integrin in the fibroblasts of keloids and hypertrophic scars were higher than normal skin; the expression of alpha5beta1 integrin in the fibroblasts of keloids was higher than hypertrophic scars (P < 0.01).
CONCLUSIONThe alpha5beta1 integrin appears to have close relation to the formation and development of abnormal scars. To find a way to decrease the expression level of alpha5beta1 integrin in fibroblasts may be a new approach to inhibit scar hypertrophy.
