Immunological effects of polyacrylamide hydrogel injection in human body.
- Author:
Xiao-ling FENG
1
;
Chuan-xun YI
;
Yi-ming ZHANG
;
Yi-ming WANG
;
Yu-rong WANG
;
Chong PENG
;
Ming YANG
;
Wei-wei LI
Author Information
- Publication Type:Journal Article
- MeSH: Acrylic Resins; adverse effects; Adult; Breast; surgery; Complement C3; analysis; Complement C4; analysis; Humans; Immunoglobulin A; blood; Immunoglobulin G; blood; Immunoglobulin M; blood; Male; Nephelometry and Turbidimetry; Postoperative Complications; etiology; immunology
- From: Chinese Journal of Plastic Surgery 2004;20(5):349-350
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the immunologic changes in patients who have complications after polyacrylamide hydrogel (HPG) injection.
METHODSTo compare the patients in the HPG injection group and the control group, the expressions of immunoglobulin IgG, IgM, IgA and complement C3, C4 of serum were measured by immunoturbidimetry.
RESULTSThe expressions of IgG and C3 in the injection group were lower than the control group with extremely significant difference (P < 0.01). The expressions of IgM were higher than the control group with significant difference (P < 0.05). The expression of IgA and C4 had no significant differences between the two groups. The immunologic changes had no relation to the injection doses.
CONCLUSIONSClinical application of HPG as a soft tissue filling material may cause foreign-body rejection reaction. The long-term immunologic effect of HPG needs further observation in more cases.
