Pressure-induced expression of immediate-early gene product c-Jun of the common carotid arteries in rats.
- Author:
Zhiqiang YAN
1
;
Zonglai JIANG
;
Yan ZHANG
;
Xiangqun YANG
Author Information
1. Laboratory of Biomechanics, School of Medicine, Shanghai Jioatong University, Shanghai 200030, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biomechanical Phenomena;
Carotid Artery, Common;
cytology;
metabolism;
physiology;
Genes, Immediate-Early;
Male;
Muscle, Smooth, Vascular;
cytology;
metabolism;
Pressure;
Proto-Oncogene Proteins c-jun;
biosynthesis;
genetics;
Rats;
Rats, Sprague-Dawley;
Stress, Mechanical
- From:
Journal of Biomedical Engineering
2005;22(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the mechanism of mechanical stress-mediated arterial remodeling, we studied the pressure-induced expression of immediate-early response gene product c-Jun in common carotid arteries in rats. The common carotid arteries were perfused with both high pressure (160 mmHg) and normal pressure (80 mmHg) for 0.5, 1, 3 and 6 hours. Expression of immediate-early response gene product c-Jun in the arteries was examined by immunohistochemistry and computer image processing. c-Jun was weakly expressed at 1 h, then increased at 3 h and 6 h after exposure of the arteries to normal pressure. Positive immunohistochemical product of c-Jun appeared in the arteries at 0.5 h after the onset of high pressure, then it increased markedly till 6 h. There was significant difference between the two groups. These results indicate that expression of c-Jun of the arteries can be induced by pressure, which may play an important role in mechanical stress-mediated arterial remodeling.
