Effect of chemotherapy to ovary function in ovarian malignancy patients undergoing conservative surgery.
- Author:
Zheng-yi SUN
1
;
Keng SHEN
;
Jing-he LANG
;
Hui-fang HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Amenorrhea; etiology; Child; Estradiol; blood; Female; Follicle Stimulating Hormone; blood; Humans; Luteinizing Hormone; blood; Menstruation; Ovarian Neoplasms; drug therapy; surgery; Ovariectomy; Ovary; physiopathology
- From: Acta Academiae Medicinae Sinicae 2003;25(4):431-433
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the effect of chemotherapy on ovarian endocrine function and menstruation.
METHODSMenstruation and serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol (E2) levels were observed when the patients with ovarian cancer undergoing one side ovarectomy were followed by chemotherapy.
RESULTSAbnormal menstruation occurred in 86.7% cases, including 80% amenorrhea and 6.7% oligomenstruate. Menstruation resumed around 2 months after chemotherapy. Serum LH, FSH levels rose and E2 level declined during amenorrhea. No significant change was observed in progesterone or testosterone levels.
CONCLUSIONSOvary function impairment may occur in ovarian cancer patient treated by one side ovarectomy followed by chemotherapy. Serum LH, FSH, and E2 levels change and abnormal menstruation are two common manifestations. However, chemotherapy-related amenorrhea is reversible.
