Effect of nitric oxide in vestibular compensation.
- Author:
Zi-dong JIANG
1
;
Lian-shan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adaptation, Physiological; Animals; Brain Stem; metabolism; physiopathology; Evoked Potentials, Auditory, Brain Stem; Female; Gentamicins; Guinea Pigs; Male; Nitric Oxide; metabolism; Nitric Oxide Synthase; metabolism; Vestibular Nerve; metabolism; Vestibular Nuclei; metabolism; physiopathology; Vestibule, Labyrinth; injuries; metabolism; physiopathology
- From: Acta Academiae Medicinae Sinicae 2003;25(5):612-614
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of nitric oxide (NO) in vestibular compensation after unilateral vestibular deafferentation.
METHODSEighteen animals were divided into two groups, 6 of group a as control, 12 of group b received gentamicin intratympanic injection in the left ear. Half of the animals were killed respectively after 5 days and 10 days. Vestibular endorgan and brainstem tissue sections were subjected to NADPH-d reactive test of NOS for histochemical examination.
RESULTSIn group a, NOS-like reactivity in both sides of vestibular endorgan and nucli. In group b during 5 days, NOS-like reactivity in right side of vestibular endorgan and nucli, those of the left side were negative. During 10 days, NOS-like reactivity only in the right side of vestibular endorgan.
CONCLUSIONSChanges of NOS expression in the contralateral vestibular nucli might have played a role in vestibular compensation.
