Serum anti-titin antibody in patients with myasthenia gravis.
- Author:
Yan-feng LI
1
;
Jun-bao ZHANG
;
Li-ying CUI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Antibodies; blood; Connectin; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Muscle Proteins; immunology; Myasthenia Gravis; complications; diagnosis; immunology; Protein Kinases; immunology; Thymoma; complications; diagnosis; immunology; Thymus Neoplasms; complications; diagnosis; immunology
- From: Acta Academiae Medicinae Sinicae 2003;25(6):725-727
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical significance of serum anti-titin antibody level in the diagnosis of myasthenia gravis (MG) with thymoma.
METHODThe serum anti-titin antibody was analysed by ELISA method in 40 cases of health control group, 90 cases of MG, 17 cases of MG with thymoma and 7 cases of no-MG thymoma. The positive rate was compared among these groups.
RESULTSThe positive rate of anti-titin antibody was significantly higher in MG with thymoma patients than MG patients (94% and 3%, P < 0.01). According to the Osserman's classification, anti-titin antibody was present mostly in patients (43%) in IV stage, and also present in 2 cases of 7 who with no-MG thymoma.
CONCLUSIONSerum anti-titin antibody test is helpful in the diagnosis of MG with thymoma.
