Radionuclide reporter gene imaging.
- Author:
Zhen-wei ZHANG
1
;
Xue-mei ZHANG
;
Hua WU
Author Information
1. Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. zwzhang@sibs.ac.cn
- Publication Type:Journal Article
- MeSH:
Gene Expression Regulation;
Gene Transfer Techniques;
Genes, Reporter;
genetics;
Genes, Transgenic, Suicide;
genetics;
Genetic Therapy;
Genetic Vectors;
Magnetic Resonance Imaging;
methods;
Molecular Biology;
Radionuclide Imaging;
Transfection
- From:
Acta Academiae Medicinae Sinicae
2003;25(6):728-730
- CountryChina
- Language:Chinese
-
Abstract:
Molecular nuclear imaging techniques are currently being developed to map the topography and level of gene expression following gene therapy. To date, two radionuclide-based imaging strategies have been investigated--using reporter genes encoding either intracellular enzymes or cell-surface receptors. In this article, we discuss these two reporter gene imaging systems that have been developed to detect gene expression noninvasively.
