Using chemical methods to crosslink xenogeneic heart valves: the progress of bioprosthetic heart valves.
- Author:
Lin LIN
1
;
Ying-wu TANG
;
Rui CHANG
;
Jian-ye ZHOU
;
Jing-wei CUI
;
Sheng-shou HU
;
Fu-shi ZHANG
Author Information
1. Department of Chemistry, Tsinghua University, Beijing 100084, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bioprosthesis;
Calcinosis;
Cross-Linking Reagents;
Glutaral;
Heart Valve Prosthesis;
Heart Valve Prosthesis Implantation;
Humans;
Photochemistry
- From:
Acta Academiae Medicinae Sinicae
2003;25(6):735-737
- CountryChina
- Language:Chinese
-
Abstract:
Glutaraldehyde clinically is the most commonly accepted crosslinking reagent for bioprosthetic valves preparation. Glutaraldehyde-treated tissue is stable against chemical and enzymatic degradation; however, its calcification and cytotoxicity are severe. Dye-mediated photooxidation is an alternative tissue preservation method that oxidizes the protein with visible light in the presence of a suitable photosensitizer. This article reviews chemical mechanism, research progress, clinical applications future development of these two methods.
