Structure and degradation property of the PVA-collagen complex drug membrane.
- Author:
Yi LIANG
1
;
Ling-rong LIU
;
Qi-qing ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Biocompatible Materials; chemistry; Collagen; chemistry; ultrastructure; Humans; Membranes; Polyvinyl Alcohol; chemistry; Spectroscopy, Fourier Transform Infrared
- From: Acta Academiae Medicinae Sinicae 2004;26(1):18-23
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the structure and degradation property of the polyvinyl alcohol (PVA)-collagen complex drug membrane.
METHODSDrug collagen membrane was complexed with PVA. The physical and chemical properties of the membrane were characterized by transmission electron microscopy, scanning electron microscope, forier transform-infrared spectroscopy and differential scanning calorimetry. Degradation experiment was performed to determine the degradation property of membrane and a degradation curve was therefor drawn.
RESULTSThe thermodynamic stability of collagen membrane was not destroyed by adding PVA. Collagen had good compatibility with PVA. Compared with collagen membrane, collagen-PVA complex membrane had smaller and evener pores. Adding PVA decreased the degradation rate of membrane.
CONCLUSIONSPVA-collagen membrane has better microstructure and antidegradation property than collagen membrane.
