Expression of macrophage colony stimulating factor in brains of PDAPPV717I transgenic mice.
- Author:
Jian-min ZHANG
1
;
Qing-li KONG
;
Hong WANG
;
Chuan QIN
;
Wei HE
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; genetics; metabolism; Animals; Brain; metabolism; Female; Immunohistochemistry; In Situ Hybridization; Macrophage Colony-Stimulating Factor; biosynthesis; genetics; Male; Mice; Mice, Transgenic; RNA, Messenger; biosynthesis; genetics
- From: Acta Academiae Medicinae Sinicae 2004;26(1):62-65
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the expression and distribution of macrophage colony stimulating factor (M-CSF) in brains of PDAPPV717I transgenic mice.
METHODSWe detected the expression and distribution of M-CSF mRNA in brains of PDAPPV717I transgenic mice by using hybridization in situ and immunohistochemical staining.
RESULTSExpression of M-CSF mRNA was significantly higher in brains of PDAPPV717I transgenic mice than that in non-transgenic mice, and M-CSF mRNA in brain was mainly produced by reactive astrocytes.
CONCLUSIONThe results indicate that astrocytes play an important role in the onset/development of neuropathology of Alzheimer's disease.
