No association of AhR gene 1661G/A and ARNT gene 567G/C polymorphisms with endometriosis in southern Han Chinese women.
- VernacularTitle:中国南方妇女AhR和ARNT基因多态性与子宫内膜异位症的相关性
- Author:
Yu-feng WANG
1
;
Li-li ZONG
;
Xin ZHAO
;
Ting MAO
;
Yong-gui FU
;
Jun ZENG
;
Xing-qiang RAO
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Aryl Hydrocarbon Receptor Nuclear Translocator; genetics; China; Endometriosis; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Polymerase Chain Reaction; methods; Polymorphism, Single Nucleotide; Receptors, Aryl Hydrocarbon; genetics
- From: Chinese Journal of Medical Genetics 2011;28(2):195-198
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association between the arylhydrocarbon receptor gene (AhR) 1661G/A or arylhydrocarbon nuclear translocatorgene (ARNT) 567G/C polymorphism and endometriosis in southern Han Chinese women.
METHODSThe polymorphisms of AhR gene 1661G/Aand ARNT gene 567G/C in 431 cases of endometriosis and 499 healthy women were genotyped by fluorescence quantitative PCR-based high resolution melting.
RESULTSThe frequencies of genotypes AA, AG, GG and alleles A and G in controls were 12.0%, 41.9%, 46.1%, 33.0% and 67.0%, respectively, which were not significantly different from those in patients with endometriosis (9.7%, 44.6%, 45.7%, 32.0% and 68.0%, respectively). The genotype frequencies of GG, GC, CC and alleles C and G in controls (15.6 %, 51.7%, 32.7%, 58.5%, 41.5%) were not significantly different from those in patients with endometriosis (13.5%, 47.8%, 38.7%, 62.6%, 37.4%), either. And no interaction of AhR 1661G/A and ARNT 567G/C on endometriosis was found.
CONCLUSIONNo association between AhR 1661G/A and ARNT 567G/C genetic polymorphisms and endometriosis was found in the southern Han Chinese women in this study.
