An association study of COMT gene polymorphisms with schizophrenia.
- Author:
Fan-zhi KONG
1
;
Zhi-zhen PENG
;
Ting-yun JIANG
;
Xiao-hong HONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Catechol O-Methyltransferase; genetics; China; Female; Genetic Predisposition to Disease; Humans; Male; Polymorphism, Single Nucleotide; Schizophrenia; enzymology; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2011;28(2):208-211
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between 8 polymorphisms in the catechol-O-methyl transferase gene (COMT) and schizophrenia in Yuedong-Chaoshan region of China.
METHODSEight single nucleotide polymorphism (SNPs), namely rs4680, rs4818, rs165599, rs737865, rs2075507, rs6267, rs6269 and rs4633, in the COMT gene were genotyped in 279 schizophrenia patients and 100 healthy controls.
RESULTSThere was no significant difference between any single SNP and schizophrenia. However, association might exist between haplotypes (G)-G-A-A [(rs4680)-rs165599-rs2075507-rs6269] and A-A-C-(G) [rs2075507-rs6269-rs4633-(rs6267)] and schizophrenia.
CONCLUSIONIn the population of Yuedong region of China, the eight SNPs (rs4680, rs4818, rs165599, rs737865, rs2075507, rs6267, rs6269 and rs4633) in the COMT gene are unlikely to play a major role in the susceptibility to schizophrenia. There might be protective haplotypes in the COMT gene against schizophrenia.
